The development of new ROMP-derived oligomeric phosphorus reagents (oligomeric benzyl phosphates, oligomeric triazole phosphates), chromatography-free Mitsunobu protocols and surface-initiated polymerization from Nb-tagged silica (Nb-Si) and Nb-tagged Cobalt-graphite (Nb-Co/C) magnetic nanoparticles for use in parallel synthesis are reported. A Monomer-on-Monomer (MoM) Mitsunobu protocol utilizing norbornenyl-tagged benzylethyl azodicarboxylate (Nb-BEAD) and Nb-tagged triphenylphosphine (Nb-TPP) is presented whereby purification/ sequestration of Nb-tagged reagents is rapidly achieved using ring-opening metathesis (ROM) polymerization. Additional efforts utilizing surface-initiated polymerization from Nb-tagged silica (Nb-Si) and Nb-tagged Cobalt-graphite (Nb-Co/C) magnetic nanoparticles is also discussed. Application of Silica supported ROMP Reagents in Flow through cartridge for the syntheses of small molecule have been carried out in purification-free process.

ROMP-derived oligo phosphate reagents: Synthesis and application in parallel and flow platforms

243rd National Meeting (2012)

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