Destabilization of tubulin, inhibits polymerization of cancerous cells, leading new pathways for the prevention of cancer and guides the discovery of drugs with this potential.  Analogue compounds of combretastatin A-4 and the inclusion of chalcones scaffold have been reported with biological and pharmacological properties.  Furthermore, ferrocene advantages and specific properties described for decades, impart the attention to lead our research design.  Based on this we are ??synthesizing and studying ferrocenyl derivatives. Ferrocenyl chalcones have been synthesized from moderate to good yields in our laboratory, which are precursors, as indicated in the literature, for multiple functional group interconvertion.  Likewise, heterocyclic compounds have attracted our attention due to their anticancer potential, cytotoxicity, and biological activity.  We propose that the incorporation of heterocycles in the chalcone core will open new approaches to a synthetic conglomerate of products that can present biological activity.  To have a discriminatory agent in relation to the compounds to be synthesized in the investigation, an examination by molecular modeling has been taken into account.  This theoretical parameters give us an idea where to direct our efforts and determine a rational drug design that can be modified or re-evaluated.  Moreover, different methodologies have been tried for epoxides derivatives synthesis.  These compounds have been difficult to achieve, and several methods have been tried without successful results.  However, the development of an efficient epoxidation method will be explored in our laboratory to achieve our specific goal.  Furthermore, the synthesis of isoxazole derivatives has been started and will be developed further.  The synthetic methodology and characterization of these compounds will be elaborated.

Heterocycles functionalizing ferrocenyl chalcones core

243rd National Meeting (2012)

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