In recent years, considerable growth of interest of organometallic chemistry in terms of their use in medicinal science, such as anticancer or antineoplastic drugs is observed. The main area of interest is focused on compounds containing metallocene fragment (eg. ferrocenyl group) and a biologically active moiety.Paclitaxel is one of the widely used anticancer drugs that inhibit tubulin depolymerization. Herein we present the first example of synthesis and anticancer activities study of ferrocenyl taxol analogues. Synthesized new ferrocenyl compounds exhibit antitumor activity against SW620 cells at the level of 0.3-0.5 uM (1.74 uM Pacitaxel).

Synthesis and antitumor activities of ferrocenyl derivatives of Paclitaxel

243rd National Meeting (2012)

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