Micelle-based drug delivery systems made from amphiphilic block copolymers have proven to be an attractive method of delivering poorly soluble drugs. PEG-DSPE micelles have been successfully used for the solubilization of several hydrophobic drugs but generally lack sustained stability in blood. Our novel PEG-Fluorocarbon-Phospholipid containing polymers were designed to increase micelle stability and improve time-release properties of drug-loaded micelles. Particle size analysis, encapsulation properties, and in vitro release profile of the micelles with Amphotericin B were investigated. F�rster Resonance Energy Transfer  was utilized to analyze particle stability in human serum. The fluorocarbon placed between hydrophilic and hydrophobic block enhanced thermodynamic stability of micelles and contributed to the sustained release of encapsulated drug. Furthermore, we have synthesized block copolymers with a hydrophilic PEG block and substituted polyaspartamides as the hydrophobic and fluorophilic blocks to study the effect of size and location of the fluorous block on micelle stability and drug delivery.

Synthesis and self-assembly of semi-fluorinated polymeric micelles for delivery of hydrophobic drugs

243rd National Meeting (2012)

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