Our research in Bioinorganic Chemistry involves: (i) The use of electron-nuclear double resonance (ENDOR), a combination of NMR and EPR spectroscopies, to determine metalloenzyme mechanisms. One major focus is on enzymes with diatomic substrates, the essential toxin, O2, and N2, the biological source of NH3. (ii) The study of long-range electron transfer (ET) between proteins, with primary focus on the central question: how do conformational dynamics at a protein-protein interface control ET?This presentation will emphasize the first of these areas. It will select from among current efforts to determine the structure and bonding in nitrogenase intermediates and their biomimetic analogues, and to characterize other systems, such as the diiron intermediate formed during activation of ribonucleotide reductase. Efforts will be made to place embed current work in the context of earlier studies. None of this work could have been accomplished without the 'help' of friends whose contributions will be highlighted.

Award Address  (Alfred Bader Award in Bioinorganic or Bioorganic Chemistry sponsored by the Alfred R. Bader Fund). With a little help from my friends

243rd National Meeting (2012)

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