Transition metal catalyzed aldehydic C-H bond activation combined with C-C bond formation have allowed us to explore novel transformations such as olefin hydroacylation. While rhodium catalyzed intramolecular olefin hydroacylation to give cyclic ketones is a well-studied methodology,1 corresponding intramolecular olefin hydroesterification to produce lactones have not received much attention. This poster will present an asymmetric and atom-economical approach to chiral lactones via olefin hydroesterification. Preliminary results showed that the size of lactone products can be controlled depending on transition metal catalysts.  1 Willis, M. C. Chem. Rev. 2010  , 110, 725.

Transition metal catalyzed asymmetric hydroesterification of olefin

243rd National Meeting (2012)

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