a-Helices are important in controlling protein-protein interactions (PPIs). We are investigating if 1  can be used as an a-helix mimetic and disrupt PPIs. Computational studies of 1  have revealed that 1  can adopt a helical configuration and place the interacting substituents in the correct orientation. We will present the design, synthesis and inhibitory activity of diketopiperazine-based inhibitors of PPIs with the general structure 1  .

Diketopiperazine-based inhibitors of protein-protein interactions

243rd National Meeting (2012)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.