A library of 1,3-disubstituted isopropanols was synthesized and evaluated as novel small molecular scaffold for �-secretase inhibition. By screening a library of 150 1,3-disubstituted isopropanol derivatives against �-secretase, we identified several low micromolar inhibitors. Upon further SAR studies, we optimized these initial hits into nanomolar inhibitory probes for �-secretase.

Synthesis and SAR analysis of 1,3-disubstituted isopropanols as novel scaffold for β-secretase inhibition

243rd National Meeting (2012)

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