The development of new nitration processes usually starts at bench-scale or pilot plant sizes.  The path of development is very specific to the particular nitration process to be investigated.  Some nitration processes can be particularly hazardous; others can be hard to scale up or control.  Many of these challenges can be difficult to manage, especially when considering a new nitration process where little or no published data is formerly available. This paper presents an overview of development challenges particular to bench-scale or pilot nitration work, and explores practical design considerations that have proven to work in the proper management of these challenges.  In particular, safety, environmental, and scale up issues are discussed, as well as measuring, sampling, and analytical techniques.

Bench-scale and pilot plant nitration experiments: Practical considerations

243rd National Meeting (2012)

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