A palladium-catalyzed method for the C�H bond functionalization of the ?� and d� positions of amine derivatives was developed.  Functionalization of the sp2 and sp3 C-H bonds employs 2-picolinic acid as directing group. A variety of aryl and alkyl iodides provided good yield of products.  Cyclization to form five� and six�membered rings was also achieved.

Palladium-catalyzed C-H bond functionalization of amine derivatives

243rd National Meeting (2012)

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