A method for the synthesis of benzyl aryl thoethers from protected thiols has been developed and optimized. In situ deprotection is utilized to generate the reactive free thiol species from thioacetates, which subsequently undergo palladium-catalyzed arylation. Thioethers are obtained in good to excellent yields from an array of sterically and electronically diverse aryl halides and thioesters. The observation of aryl/aryl exchange with Xantphos is also discussed.

Palladium-catalyzed cross-coupling of benzyl thioacetates and aryl halides

243rd National Meeting (2012)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.