An intramolecular regioselective and stereoselective Pd(II)-catalyzed coupling of boronate esters with alkene or alkyne insertion has been developed. This methodology provides convenient access to substituted fused or spiro polycyclic ring systems. The reaction involves competing transmetallations and insertions. Furthermore, we have designed substrates that explore the competitive rates of vinyl and aryl transmetallation versus alkene and alkyne insertion.

Palladium(II) catalyzed intramolecular insertions for polycyclic ring synthesis

243rd National Meeting (2012)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.