The piano stool Ru(II) complexes, such as CpRuCl(cod), catalyze the intermolecular [2+2+2] cycloaddition of 3-halopropargylic amides and alkynes leading to fully substituted, dihalogenated benzenes with excellent chemoselectivity and high regioselectivity. Haloalkynes are necessary reaction partners playing a crucial role in increasing the regioselectivity of the cyclotrimerization of activated alkynes. The reaction is experimentally simple and proceeds at ambient temperature in ethanol without special precautions.

Ruthenium(II)-catalyzed intermolecular [2+2+2] co-trimerization of haloalkynes with internal and terminal alkynes

243rd National Meeting (2012)

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