A simple and efficient total synthesis of (�)-flinderoles A-C, members of a new class of antimalarial bisindole alkaloids isolated from plant of the Flindersia genus. Key steps include: Lewis acid catalyzed intramolecular Friedel-Crafts alkylation that establishes pyrrolo[1,2-a]indole core with isobutenyl functionality and Pd-catalyzed cross-coupling reaction.

Total synthesis of flinderoles A-C by diastereoselective intramolecular Friedel-Crafts  cyclizations of N-acyl indoles

243rd National Meeting (2012)

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