Comparative gene identification isolate 112 (CGI-112) is a recently discovered human gene that encodes for a protein of unknown structure and function. Although the gene's proximal location and shared regulation with cytochrome oxidase originally suggested a potential role in mitochondrial electron transport, more recent studies have shown that CGI-112 may be involved in proteolysis or interact with the tetratricopeptide-repeat protein (TTC35), which implies an involvement in programmed cell death, cell division, and intracellular transport. Circular dichroism spectra of the CGI-112 protein have been determined at several pH values to assess overall secondary structure content and stability. Experimental results are compared to predictions of secondary structure content produced using a variety of algorithms.

Secondary structural analysis of the CGI-112 protein

243rd National Meeting (2012)

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