Deoxyribonucleic acid (DNA) is an essential biomolecule whose importance spans various disciplines from passing on genes from one generation to another to controlling the production of proteins in living organisms to criminal cases. Since it's discovery, the structure of DNA has been modified in order to modulate its function. Nucleotide modifications have focused on synthetically modifying the sugar, backbone or nucleobase.Our research has focused on nucleobase modification, specifically at the 5 position of the pyrimidine nucleus. This study will focus on a series of 5-aryl modified pyrimidines that have been incorporated into a 15-mer strand of DNA. The thermodynamic stability of these modified oligonucleotides will be investigated and compared to native control strands as well as previously investigated modified oligonucleotides.

Investigating the major groove of DNA with modified nucleosides: Thermal denaturation

243rd National Meeting (2012)

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