Polydiacetylene liposomes can be used as biosensors for Phytophthora sojae. These liposomes were synthesized from 10,12-pentacosadiynoic acid (PCDA) and a variety of amino acid derivatives to which the zoospores of the Phytophthora are attrachted. Research this summer focused on two methods for synthesizing the amino acid derivatives used to make the liposomes. The first method is a two-step synthesis involving N-hydroxysuccinimide. The second method is a one step process involving the catalyst T3P (propane phosphonic acid anhydride). The T3P method was found to be the more effective method because both methods produce the same products, have comparable yields, and is less time consuming than the NHS ester method. The liposomes were then tested on lipopolysaccharide solutions from E.coli, Salmonella enterica, Klebsiella pneumoniea, Pseudomonas aeruginosa.

Synthesis of polydiacetylene liposomes as a biosensor for <i>Phytophthora sojae: </i>A comparison of two methods

243rd National Meeting (2012)

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Synthesis of polydiacetylene liposomes as a biosensor for Phytophthora sojae: A comparison of two methods