Natural products have provided perennial inspiration for the development of synthetic methods, and enzymes have provided an analogous platform for the conception of new catalysts.  This lecture will recount an interplay of experiments stimulated by these two major classes of naturally occurring substances.  Specifically, the discovery and use of peptides as catalysts for a variety of asymmetric bond formations will be presented.  Likewise, applications of these catalysts to the synthesis and selective modification of complex molecules, including biologically active natural products, will be described. A particular emphasis will be placed on reactions that present unusual stereochemical challenges.

Natural products, synthetic catalysts, unnatural products

243rd National Meeting (2012)

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