Practical new methods for carbon-carbon bond formation will be described that enable the efficient preparation of amine containing compounds. Additions to N-tert-butanesulfinyl imines, enantioselective reactions catalyzed by N-sulfinyl ureas, and Rh(I)- and Rh(III)-catalyzed C-H bond functionalization will be presented with an emphasis on regio- and stereoselective entry to pharmaceutically relevant classes of chiral amines and nitrogen heterocycles. The utility of these methods will be demonstrated with syntheses of bioactive natural products and drugs.

Award Address  (Herbert   C. Brown Award for Creative Research in Synthetic Methods sponsored by the   Purdue Borane Research Fund and the Herbert C. Brown Award Endowment). New methods for the synthesis and elaboration of amine containing compounds

243rd National Meeting (2012)

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