The bioavailability of organometal compounds can be improved by conjugation to carrier systems like cell-penetrating peptides (CPPs). The combination of bioactive metal moiety, linker, and amino acid sequence strongly influences cellular uptake, intracellular distribution, and biological activity. In the present contribution, peptide bioconjugates based on CpM(CO)3 half-sandwich complexes and their activity on human cancer cell lines will be discussed.[1] W. Hu, K. Splith, I. Neundorf, K. Merz, U. Schatzschneider, J. Biol. Inorg. Chem. 2011  , DOI:10.1007/s00775-011-0840-5.[2] K. Splith, W. Hu, U. Schatzschneider, L.A. Onambele, A. Prokop, R. Gust, I. Ott, I. Neundorf, Bioconjugate Chem. 2010  , 21, 1288-1296.[3] K. Splith, I. Neundorf, W. Hu, H.W. Peindy N'Dongo, V. Vasylyeva, K. Merz, U. Schatzschneider, Dalton Trans. 2010  , 39, 2536-2545.[4] I. Neundorf, J. Hoyer, K. Splith, R. Rennert, H.W. Peindy N'Dongo, U. Schatzschneider, Chem. Commun. 2008  , 5604-5606.

Organometal compounds and their bioconjugates: Applications in anticancer chemotherapy and bioanalytics

243rd National Meeting (2012)

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