Vanadium compounds are known insulin-enhancing agents, and as such a range of derivatives have been investigated for potential treatment (1).  The mode of action of these compounds is generally presumed through the inhibition of protein tyrosine phosphatases.  Recent investigations into a potential role of the membrane function have led to studies investigating the interactions of a range of metal complexes with the lipid interfaces.  These studies in turn have led to the exploration of how the lipid-like environment affects the interaction of metal complexes in general.  The characterization of the nanosized materials in combination with animal studies have allowed testing approaches to make materials that can be used for administration of a drug in tandem with targeting agent or co-drug. Lipid gels loaded with carboplatin and the targeting agent cholesterol were intracavitary administered after surgical removal of tumors (2). Formulations have been designed with the concept of promoting a synergistic relationship between the drugs, coupling taxol's anti-sarcoma potency with bisphosphonate agent's tendency to concentrate at bone resorption sites as well as its treatment of hypercalcemia correlated with cancer malignancy. Model studies carried out using NMR and Langmuir monolayer studies combined with dynamic light scattering data with either the anionic AOT or the catonic surfactant cetyl trimethylammonium bromide (CTAB) systems documented the formation of organized self assemblied structures in the formulations tested. (1) Debbie C. Crans, Alejandro M. Trujillo, Philip S. Pharazyn, and Mitchell D. Cohen Coor. Chem. Rev. 2011 , 19-20, 2178-2192.(2) Kellie A. Woll, Elie J. Schuchardt, Claire R. Willis, Christopher D. Ortengren, Ernestas Gaidamauskas, Deanna R. Worley, David W. Osborne and Debbie C. Crans Chemistry & Biodiversity 2011  in press.

Journey from probing how antidiabetes drugs act to formulation of anticancer agents

243rd National Meeting (2012)

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