Lead, and heavy metal poisoning is a major pediatric health problem in the USA, and especially in New York City and the Brooklyn. Our project involves design, preparation and characterization of new sensors and chelators for analysis and removal of toxic metal ions such as lead, mercury, and cadmium from the environment. We have achieved remarkable progress in this area by developeing a new sensor based on a coumarin ligand that we synthesized, which can sense and bind cadmium selectively. The coumarin chromophore fluoresces, when bound to lead and cadmium ions, even at very low levels of these toxic heavy metal ions. Presently, studies are underway with a new pyrazoline-based ligand. As a part of our characterization study, we resolved the X-ray crystal structure of the pyrazoline-based ligand. The compound exists as a racemic mixture. The results of this X-ray structure resolution will be presented.

Development of pyrazoline-based ligands as selective toxic heavy metal sensors and chelators

243rd National Meeting (2012)

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