Drug resistance has been a serious challenge since the discovery of the first antibiotics, as bacteria develop strategies to overcome the mechanism of these critical medications. The importance of developing new, unique antibiotics to combat bacterial infections is universally accepted. We have previously identified a series of bisamidines, based on a heterocyclic framework, that are potent antibacterials. Recent investigations have demonstrated some key features that are responsible for modulating the effect of efflux pumps (one key resistance mechanism) in this series of compounds. We will discuss key features of the molecules and how they influence antibacterial resistance via efflux.

Antibacterial bisamidines: Features modulating efflux

243rd National Meeting (2012)

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