The ability to inhibit two pancreatic cancer cell lines, AsPC-1 and PANC-1, was studied for metal-containing polymers containing the Lewis bases thiamine, 3,5-pyridinedicarboxylic acid and isomannide.  Chemotherapeutic index, CI, values were determined using NIH-3T3 cells.  Some of the compounds showed CI values on the order of 1,000 and above.  Several (tentative) observations were apparent.  Only polymers containing organotin showed the good CI50  or GI50 values.  The nature of the organotin moiety is important in determining the growth inhibition. Polymers containing the dibutyltin and diphenyltin moiety generally exhibit good to outstanding ability to arrest the growth of the pancreatic cells.  For the isomannide products, inhibition of the AsPC-1 cell is mild but inhibition of the PANC-1 cell line is good to outstanding.   The compounds were more effective at arresting the growth of the PANC-1 cell compared with the AsPC-1 cells.

Inhibition of pancreatic cancer cell lines by metal-containing polymers derived from thiamine, 3,5-pyridinedicarboxylic acid and isomannide

243rd National Meeting (2012)

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