Compared with conventional therapeutic systems, drug and gene delivery systems offer numerous advantages. Our studies were focused on the functional peptides and polymers for drug and gene delivery. To endow the delivery systems with active targeting property, studies have been carried out on the incorporation of various targeting ligands including particular cell penetrating peptide sequences, RGD sequence, transferrin, galactose, and folate to drug and gene delivery systems through covalent bonds and biotin-avidin interaction. To endow the delivery systems with stimuli responsibility, we designed and prepared various types of nanoparticulate drug delivery systems with stimuli responsibilities including pH, temperature, redox potential, and light sensitivities. These drug and gene delivery systems exhibited improved drug controlled release properties and enhanced gene transfection efficiencies. In addition, the targeted delivery to particular tissue and tumor cells could be achieved through incorporation of particular targeting ligands.

Functional peptides and polymers for drug and gene delivery

243rd National Meeting (2012)

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