Many membrane proteins are responsible for transporting various chemical species in and out of cell membranes. However, it is difficult to directly probe the conformational dynamics of membrane proteins, especially the large-scale motions related to function. In this talk, an example will be given to show that fluorescence fluctuations of individual protein molecules could be used to reveal functionally relevant motions of membrane proteins. In addition, examples will be presented to show how peptide binding affects the dynamics of individual lipids in model membranes.

Single-molecule study of membrane and membrane protein dynamics

243rd National Meeting (2012)

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