Zinc is an essential transition metal that is involved in biological processes such as brain function and pathology, gene transcription, immune function, and mammalian reproduction. Zinc is known to be secreted from an oocyte right after fertilization, which indicates that zinc may play an important role in fertility.1 In order to study zinc's role in the oocyte, we are synthesizing immobilized fluorescent zinc sensors. The synthesis of these zinc sensors, as well as their in vitro spectroscopic characterization and biological application in reproductive biology will be presented.(1) Kim, A.M.; Bernhardt, M.L.; Kong, B.Y.; Ahn, R.W.; Vogt, S.; Woodruff, T.K.; O'Halloran, T.V. (2011) Zinc sparks are triggered by fertilization and facilitate cell cycle resumption in mammalian eggs. ACS Chem. Bio. 6 (7), 716-723.

Immobilized fluorescent zinc sensors: Synthesis and applications

243rd National Meeting (2012)

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