This contribution will summarize our studies on design and development of new biological targets for platinum-metal drugs. Protonation, alkylation or coordination to a metal ion, such as Pt(II), Pd(II) or Au(III) of a nucleobase generally decreases the energy of its lowest unoccupied molecular orbital (LUMO), thereby improving the potential for pi-stacking interactions with the highest occupied molecular orbital (HOMO) in aromatic aminoacids such as N-acetyl tryptophan. This consideration has prompted study of the structures as new chemotypes for inhibition of NCp7 recognition and function. The reactivity of zinc finger proteins will be reviewed with repect to recognition and selective attack by platinum-metal drugs.Quintal, S.M., dePaula, Q.A. and Farrell, N.P. Zinc Finger Proteins as Templates for Metal Ion Exchange and Ligand Reactivity. Chemical and Biological Consequences. Metallomics. 3:121-139 (2011).

Zinc finger interactions of platinum metal complexes: New drug targets

243rd National Meeting (2012)

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