Although pyridines are perhaps the most common nitrogen-donor ligands and the coordination chemistry of heterocyclic thiones is well-developed, the synthesis and reactivity of simple tridentate ligands containing a combination of such functionalities is virtually unknown.  The synthesis and reactivity of two new pyridine/thione mixed-donor ligands, the bis(pyridyl)mercaptoimidazole (2-py)2m and the bis(picolyl)mercaptoimidazole (2-pic)2m, is described herein.  Reactivity studies have led to the preparation of the group 12 metal complexes {(2-py)2m}MX2 (M = Zn, Cd, Hg; X = Cl, Br, I) and the isolation of the copper(I) derivatives {(2-py)2m}CuX (X = Br, I).  The potential application of the latter to the synthesis of structural analogues of methanobactin, a small copper-binding protein that exhibits potent antibacterial properties, will be outlined.  A detailed comparison of the metrical parameters in the structures of analogous (2-py)2m and (2-pic)2m complexes will be highlighted in this presentation. 

New [N<sub>2</sub>S] donor ligands for the preparation of synthetic analogs of methanobactin

243rd National Meeting (2012)

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New [N2S] donor ligands for the preparation of synthetic analogs of methanobactin

New [N₂S] donor ligands for the preparation of synthetic analogs of methanobactin