To enhance the oral uptake and blood drug content, it is a good choice to use nanoparticles as drug carriers. And the polymer nanoparticles had been proved to be of good biodegradability and biocompatibility.We used polylactic acid (PLA) to prepare nanoparticles by ionic gelation method and emulsification method. We characterized the particles from SEM, FT-IR and so on. Then, we try to optimize the conditions such as temperature. At the same time, we tried to encapsule the drug into the nanoparticles and calculated its entrapment efficiency and drug-loading efficiency. Besides, the drug-releasing experiment in vitro will be our further study.

Fabrication of polylactic acid(PLA) nanoparticles and its application in drug delivery

243rd National Meeting (2012)

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