Carbonic anhydrase (CA) is being used to model matrix metallproteinases (MMPs), as both are zinc-dependent enzymes that bind to zinc in a His3(OH) environment. CA is being used to screen potential zinc chelators, such as maltol, thiomaltol, acetohydroxamate and benzylacetohydroxamate, via spectroscopic examination of their binding to Zn-CA and cobalt substituted CA, using optical spectroscopy.  More detailed spectroscopy of the Zn- and Co-containing enzymes is being used to examine their binding modes.

Cobalt as a model for zinc in biological systems

243rd National Meeting (2012)

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