The study of organogold complexes has drawn increasing interest as practical applications of this chemistry including antitumor activity have been discovered.  With this in mind, we have set out to explore fundamentals of structure and bonding in gold(III) complexes.  Specifically, we have synthesized cyclometallated gold(III) square planar complexes incorporating 1,3,7-trithiacyclononane(9S3)  ligands.  These complexes were accessed through a scheme first involving the preparation of neutral intermediates of the form Au(N^CH)Cl3 (N^CH = 2-(p-tolyl)pyridine, 2-(2'-benzothienyl)pyridine).  These neutral noncyclometallated complexes were heated as neat solid complexes to induce cyclometallation.  The cyclometallated complexes of the form Au(N^C)Cl2 were then reacted with 9S3 and metathesized to access the target complex salts of the form [Au(N^C)(9S3)](PF6)2.  These systems were characterized by numerous methods including 1D and 2D NMR, electronic spectroscopy, TGA, DSC, and X-ray crystallography.

Synthesis and structural characterization of cyclometallated gold(III) complexes

243rd National Meeting (2012)

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