Purines and their N-oxide derivatives have shown biological activity that makes them promising anti-cancer agents.It has been shown that this biological activity increases upon coordination, but there are some purine N-oxides that have not been biologically tested. With this in mind, two copper complexes containing guanine 3-N-oxide (L), (H3O)[Cu3(�3-L)2(�-Cl)(�-OMe)(OMe)Cl4]�6H2O and (H3O)[Cu3(�3-L)2(�-H2O)(�-Cl)Cl6]�3H2O, were synthesized and characterized using X-ray diffraction techniques. Progress towards the synthesis of water soluble analogues of these complexes, for use in biological testing, will be presented.

Progress towards synthesizing a water-soluble copper (II) guanine 3-N-oxide complex

243rd National Meeting (2012)

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