Peptoids are a novel class of biomimetic, non-natural, sequence-specific heteropolymers that resist proteolysis, exhibit potent biological activity, and fold into higher order nanostructures. Structurally similar to peptides, peptoids are poly N-substituted glycines, where the side chains are attached to the nitrogen rather than the alpha-carbon. Their ease of synthesis and structural diversity allows the design and engineering of new biologically-active and nanostructured materials.  This tutorial will describe cheap, efficient and straight-forward protocols and strategies for the solid-phase synthesis, characterization and self-assembly of preptoid polymers.

Synthesis and self-assembly of sequence-specific peptoid polymers - a tutorial

243rd National Meeting (2012)

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