Herein, we report the modification of poly(dimethylsiloxane) (PDMS) surfaces with polycarboxybetaine (PCB) via surface-initiated atom transfer radical polymerization (ATRP). First, the PDMS surface was treated with oxygen plasma, followed by immersion into a THF/acetonitrile solution containing Br-trichlorosilane. Then, the surface-initiated polymerization of carboxybetaine was carried out. Contact angle was measured to characterize the hydrophilicity of the PCB-modified PDMS surface. Atomic force microscopy (AFM) results showed that the surface is very smooth under wet condition. The PCB modified PDMS surface was shown to highly resist non-specific protein adsorption as monitored by Enzyme-Linked Immunosorbent Assay (ELISA). Furthermore, the pCB-modified PDMS surface was also evaluated with various microorganisms.

Surface modification of poly(dimethylsiloxane) with polycarboxybetaine

243rd National Meeting (2012)

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