The copper complex of 8-hydroxyquinoline thiazole (8OHQ(oBt)) has shown indications of biological interactions.  The complex was synthesized via reaction of CuCl2 with 8OHQ(oBt) and has been fully characterized.  The X-ray crystal structure of the complex revealed a unique coordination environment around the metal center including two Cl- ions and one 8OHQ(oBt) ligand frame bound in an N,N,O fashion.  Interestingly, the quinoline hydroxyl group remains protonated.  In order to determine the structural motifs that are responsible for the interaction of this complex with DNA, we have synthesized two new Cu(II) complexes containing (8OHQ(oBt) ligand frame derivatives; one containing a deprotonated phenolate group (8OQ(oBt)-) and one containing no phenol group (Q(oBt)).  The synthesis and characterization of the new ligands and the corresponding Cu(II) complexes will be presented along with the differences in biological activity between the three complexes: Cu(8OHQ(oBt))Cl2, [Cu(8OQ(oBt))Cl2]- and Cu(Q(oBt))Cl2.

Biological interactions of Cu(II) thiazole complexes: A structure function study

243rd National Meeting (2012)

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