NaIO4-mediated carbonylation of amines provides an alternative to current methods of synthesizing formamides, which can involve high temperatures, metal catalysts, or stoichiometric equivalents of formic acid.  Although NaIO4-mediated carbonylation converts amines to ureas in non-polar solvents, the formamide can be formed from p-methoxybenzyl amine in yields as high as 91% when the reaction is performed in neat methanol.  Optimization of formamide yields, functional group compatibility, scope of the reaction, and solvent participation will be discussed.

Oxidative carbonylation of amines to formamides using NaIO<sub>4</sub>

243rd National Meeting (2012)

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Oxidative carbonylation of amines to formamides using NaIO4

Oxidative carbonylation of amines to formamides using NaIO₄