A stereoselective synthesis of 2'-deoxy-2',2'-difluorocytidine is described. The predominant product of b-nucleoside 3  obtained from the glycosylation was accomplished by reacting 1  with 2  in the presence of a transition metal salt, Ag2CO3. The glycosyaltion process is presumably via an SN1 mechanism. 

Stereoselective synthesis of b-nucleoside, synthesis of 2'-deoxy-2',2'-difluorocytidine

243rd National Meeting (2012)

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