Microwave chemistry has burgeoned in recent years, primarily within combinatorial chemistry and batch synthesis on the discovery level.  There has been a desire to perform reactions in a continuous-flow setup, permitting safe and efficient processing of large quantities of reagents.Our research team is currently advancing new technologies using flow chemistry to demonstrate the utility of a microwave based system.  Reagent concentration, temperature, time and other conditions are optimized in a practically �hands free� fashion, allowing chemists to work more efficiently.  Ideal reaction conditions can then be directly applied to nearly kilogram scale production in a day or synthesis of a library of compounds.  This presentation will focus on monophasic and biphasic reaction optimization for metal catalyzed and non-catalyzed reactions using a microwave-assisted continuous-flow reactor.  A small survey of reaction substrate scope will also be analyzed using this instrument as well as the impact of selective heating of metals in a flow chemistry setting.

Creating time in synthetic organic labs: Optimization and substrate screening using microwave flow chemistry

243rd National Meeting (2012)

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