The chemical modification of proteins requires highly active and selective reactions of the �click chemistry� variety. For certain applications, the triggered release of cargo molecules is also advantageous. The latest developments in the copper-catalyzed azide-alkyne cycloaddition reaction for bioconjugation will be described, along with the attachment and release reactions of electron-deficient oxanorbornadiene electrophiles for thiol addition.

Permanent and cleavable linkages for protein therapeutics

243rd National Meeting (2012)

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