In recent years, how the nanoscale materials affect these complex behaviors for applications in tissue engineering and regenerative medicine are being vigorously investigated. One nanomaterial of interest has been derived from plant viruses as cell supporting substrates, on which bone marrow derived mesenchymal stem cells (BMSCs) were rapidly induced towards osteogenic cells. This enhanced differentiation on the virus coated substrates was preceded by an early upregulation of a key protein, the bone morphogenetic protein-2 (BMP2), which is often supplemented in synthetic scaffolds to enhance bone formation. In this talk, we will present the early effects of tobacco mosaic virus (TMV) on osteoinduction with particular emphasis on its early BMP2 regulation.

Rapid osteoinduction by plant virus substrate mediated through early upregulation of bone morphogenetic protein-2

243rd National Meeting (2012)

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