Providing an optimal tissue scaffold is critical for the regrowth of bone at a major injury site.  In this study, calcium aluminate (CaAl) and hydroxyapatite, the mineral components of bone, were investigated as potential bone tissue scaffolds.  These materials are bioactive, easily synthesized at room temperature, and have been shown to induce de novo bone formation.  To enhance regenerative properties, the scaffolds were modified via chemical immobilization of bone morphogenetic protein 2 (BMP2), a protein responsible for enhancing bone cell growth and differentiation, and the cell adhesion peptide Lys-Arg-Ser-Arg (KRSR).  Viability of both fibroblast, a component of connective tissues, and osteoblast cell lines was examined to determine cell-binding specificity. This study effectively shows that BMP2 functionalized and KRSR functionalized calcium scaffolds selectively increase osteoblast viability as compared to fibroblast viability and enhance cell adhesive properties over unmodified scaffolds.

Modified calcium surfaces as optimum tissue scaffolds

243rd National Meeting (2012)

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