To date,vaccine has still been most effective for preventing both seasonal and pandemic flu. Although traditional egg-based influenza vaccine production has been proven effective, it suffers from several drawbacks such as a long production period. Here we present a new technology for rapid and massive influenza vaccines production. The core of this technology is based on a yeast viral antigen display system. These new vaccines are safer than viral vector-based vaccines for use in humans. Our previous work showed that yeast can effectively express functional H5N1 hemagglutinin (HA), and surface-displayed yeast vaccines can elicit protective immune responses against influenza in mice. In this work, we further optimize the expression system in order to enhance the immunogenicity of the yeast surface displayed viral antigens. Animal experiments are planned to determine the effectiveness of these new vaccines. The results will be presented at the conference.

HA displayed yeast influenza vaccine

243rd National Meeting (2012)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.