In this study, hemagglutinin proteins of several influenza A virus and related proteins were employed as the model compounds. The physico and chemical properties employed in this research are hydropath index, Log P, Gibbs Free Energy, tPSA and numbers of donors (or acceptors) of hydrogen bonds. After converting the each amino acid to the physico/chemical properties based on the previous researches, matrix consisting of the amino sequences and the properties of the amino acids was prepared. Then, the proteins were characterized and categorized based on the physico/chemical properties of amino acids not based on the alignment of the sequences. The results indicated that influenza viruses could be categorized and characterized by the new methods. For example, average of the hydropath index and Log P values of the influenza viruses are in the certain values (-1.32~1.48) and the values are different from those of another non-hemagglutinin proteins employed in this research. These results showed that our approaches can be the alternatives of the existed ones and the new way to categorize the proteins.

Establishment of new logic for the analysis of proeins based on properties of amino acids

243rd National Meeting (2012)

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