Critical to the development of stimuli-responsive nanomaterial systems is characterizing their release properties for delivery of therapeutic or diagnostic agents.  Standard methods used to obtain this information include chromatographic techniques that require sample degradation and time consuming extraction and purification before detection.  A method capable of probing the desired release characteristics in situ without having to separate the payload and delivery system would be advantageous.  The work in this talk shows fluorescence lifetime measurements can achieve this goal with several advantages over commonly used steady state fluorescence measurements.  This technique is applied to polymeric nanoparticles using a fluorescent dye that sensitively probes the complex environment found in delivery systems.

Application of fluorescence spectroscopy toward determination of controlled release in situ

243rd National Meeting (2012)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.