Different analogs of Pentamidine were made, one series of analogs had only one amidine taken away, another series had an amidine and oxygen removed, and the last series had one aromatic ring removed as well as an amidine and oxygen. Results for the first series showed that the IC50 values were a good amount higher than that of Pentamidine. Also the gel assay showed that they didn't disrupt the MBNL-RNA complex from forming as well as Pentamidine does. Results for the last two series has yet to be received, but based on previous research, the second series might give good results while the third series should not. Based on the research, we concluded that one amidine and two aromatic rings are needed to make an effective drug. However, much more research still needs to be made in order make a drug that can move on to the next testing stage.

Making pentamidine analogs as potential myotonic dystrophy drugs

243rd National Meeting (2012)

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