The skin glands of poison dart frogs contain a diverse set of alkaloids that afford a measure of chemical defense against predation.  These compounds are of interest because of their unique molecular architectures and because of their biological activity.  A painkiller 200 times more potent than morphine has been isolated from poison dart frogs, and other isolates include muscle relaxants, heart stimulants, and appetite suppressants.  Poison dart frog alkaloid 237I, a 4,6-disubstituted quinolizidine, appears to be among the isolates whose biological activity remains to be fully explored.  To that end, progress toward the total synthesis of this compound and its analogues is presented herein.

Progress toward the synthesis of poison dart frog alkaloid 237I

243rd National Meeting (2012)

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