The aim of this study was to evaluate structure-activity relationships in a class of thiophene-based SHIP2 inhibitors in an attempt to increase the affinity of the SHIP2 binding.  Analogues of the parent compound were synthesized and have been evaluated in several in vitro assays. SHIP2 is a positive regulator in the PI3K signaling pathway, a cell-signaling pathway. SHIP2 is overexpressed in many breast cancer cell lines; inhibition of SHIP2 results in decreased cell growth and cell metastasis in those cell lines. Due to these characteristics, inhibitors of SHIP2 are being investigated for potential anti-cancer drugs.

Structure-activity relationships in thiophene-based SHIP2 inhibitors

243rd National Meeting (2012)

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