DNA cleavage by free radicals is important in many cancer therapies and aryl sulfoxides have been shown to produce free radicals upon exposure to UV light. Molecules with DNA binding moieties are better DNA cleavage agents. Therefore, 9-methylsulfinylphenanthrene, an aryl sulfoxide with a polyaromatic ring system, was synthesized to potentially be used for DNA cleavage. An Ethidium Bromide Displacement Assay was used to determine the DNA binding constant for this compound and a DNA melting curve was utilized to determine the stability of DNA when 9-methylsulfinylphenanthrene is bound.

DNA binding studies of 9-methylsulfinylphenanthrene

243rd National Meeting (2012)

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