The increasing use of engineered nanoparticles (NPs) in industrial and medical applications is expected to increase unintended environmental or occupational exposures and intended medical or direct consumer exposures. The physical and chemical properties of the NP engage and activate distinct proteins and cellular pathways that, in turn, govern the fate of the NP and its impact on the cell and ultimately on human health. The relationships between particle properties and these complex cellular processes and response are still unclear. Airborne NPs that enter the respiratory tract are likely to be deposited in the alveolar region. To preserve inhaled NP properties that are presented to alveolar cells in vivo, we study cells grown and exposed to aerosolized NPs at the air-liquid interface (ALI). Here we present our findings, providing realistic relationships between airborne particle properties and their cellular fate and response. This work is funded by NIEHS grant 1RC2ES018786-01 (G.O.).

Mechanism of airborne engineered nanoparticle toxicity in alveolar cells at the air interface

243rd National Meeting (2012)

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